Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings-Reference-Cited by-同舟云学术

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

Published:2021-04-16 Issue:6539 Volume:372 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Steinmetz Nicholas A.¹²^ORCID,Aydin Cagatay³^ORCID,Lebedeva Anna⁴^ORCID,Okun Michael⁵⁶^ORCID,Pachitariu Marius⁷^ORCID,Bauza Marius⁴^ORCID,Beau Maxime⁸^ORCID,Bhagat Jai⁶^ORCID,Böhm Claudia⁷^ORCID,Broux Martijn³^ORCID,Chen Susu⁷^ORCID,Colonell Jennifer⁷,Gardner Richard J.⁹^ORCID,Karsh Bill⁷,Kloosterman Fabian³¹⁰¹¹¹²^ORCID,Kostadinov Dimitar⁸^ORCID,Mora-Lopez Carolina¹⁰,O’Callaghan John¹⁰,Park Junchol⁷^ORCID,Putzeys Jan¹⁰^ORCID,Sauerbrei Britton⁷,van Daal Rik J. J.³¹³¹⁴^ORCID,Vollan Abraham Z.⁹^ORCID,Wang Shiwei¹⁰^ORCID,Welkenhuysen Marleen¹⁰,Ye Zhiwen²^ORCID,Dudman Joshua T.⁷^ORCID,Dutta Barundeb¹⁰,Hantman Adam W.⁷^ORCID,Harris Kenneth D.⁶,Lee Albert K.⁷^ORCID,Moser Edvard I.⁹^ORCID,O’Keefe John⁴^ORCID,Renart Alfonso¹⁵^ORCID,Svoboda Karel⁷^ORCID,Häusser Michael⁸^ORCID,Haesler Sebastian³¹¹^ORCID,Carandini Matteo¹^ORCID,Harris Timothy D.⁷^ORCID

Affiliation:

1. UCL Institute of Ophthalmology, University College London, London, UK.

2. Department of Biological Structure, University of Washington, Seattle, WA, USA.

3. Neuroelectronics Research Flanders, Leuven, Belgium.

4. Sainsbury Wellcome Centre, University College London, London, UK.

5. Centre for Systems Neuroscience and Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.

6. UCL Queen Square Institute of Neurology, University College London, London, UK.

7. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

8. Wolfson Institute for Biomedical Research, University College London, London, UK.

9. Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.

10. IMEC, Leuven, Belgium.

11. Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.

12. Brain and Cognition, KU Leuven, Leuven, Belgium.

13. ATLAS Neuroengineering, Leuven, Belgium.

14. Micro- and Nanosystems, KU Leuven, Leuven, Belgium.

15. Champalimaud Centre for the Unknown, Lisbon, Portugal.

Abstract

Recording many neurons for a long time The ultimate aim of chronic recordings is to sample from the same neuron over days and weeks. However, this goal has been difficult to achieve for large populations of neurons. Steinmetz et al. describe the development and testing of Neuropixels 2.0. This new electrophysiological recording tool is a miniaturized, high-density probe for both acute and long-term experiments combined with sophisticated software algorithms for fully automatic post hoc computational stabilization. The technique also provides a strategy for extending the number of recorded sites beyond the number of available recording channels. In freely moving animals, extremely large numbers of individual neurons could thus be followed and tracked with the same probe for weeks and occasionally months. Science , this issue p. eabf4588

Funder

National Institutes of Health

Pew Charitable Trusts

Kavli Foundation

Esther A. and Joseph Klingenstein Fund

ASCRS Research Foundation

Wellcome

Agentschap Innoveren en Ondernemen

Biotechnology and Biological Sciences Research Council

Fonds Wetenschappelijk Onderzoek

KU Leuven

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