In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography-Reference-Cited by-同舟云学术

In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography

Published:1997-06-27 Issue:5321 Volume:276 Page:2037-2039
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tearney Guillermo J.¹²³,Brezinski Mark E.¹²³,Bouma Brett E.¹²³,Boppart Stephen A.¹²³,Pitris Costas¹²³,Southern James F.¹²³,Fujimoto James G.¹²³

Affiliation:

1. G. J. Tearney, B. E. Bouma, S. A. Boppart, C. Pitris, J. G. Fujimoto, Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Building 36-357, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

2. M. E. Brezinski, Cardiac Unit, Massachusetts General Hospital (Harvard Medical School), Knight Catheterization Laboratory, Fruit Street, Boston, MA 02114, USA.

3. J. F. Southern, Department of Pathology, Sinai Samaritan Hospital, Milwaukee, WI 53233, USA.

Abstract

Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter. This method, referred to as “optical biopsy,” was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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