The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide-Reference-Cited by-同舟云学术

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

Published:2013-11-22 Issue:6161 Volume:342 Page:971-976
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Viaud Sophie¹²,Saccheri Fabiana¹,Mignot Grégoire³⁴,Yamazaki Takahiro¹,Daillère Romain¹²,Hannani Dalil¹,Enot David P.⁵⁶,Pfirschke Christina⁷,Engblom Camilla⁷,Pittet Mikael J.⁷,Schlitzer Andreas⁸,Ginhoux Florent⁸,Apetoh Lionel³⁴,Chachaty Elisabeth⁹,Woerther Paul-Louis⁹,Eberl Gérard¹⁰,Bérard Marion¹¹,Ecobichon Chantal¹²¹³,Clermont Dominique¹⁴,Bizet Chantal¹⁴,Gaboriau-Routhiau Valérie¹⁵¹⁶,Cerf-Bensussan Nadine¹⁵¹⁶,Opolon Paule¹⁷¹⁸,Yessaad Nadia¹⁹²⁰²¹²²,Vivier Eric¹⁹²⁰²¹²²,Ryffel Bernhard²³,Elson Charles O.²⁴,Doré Joël¹⁵²⁵,Kroemer Guido⁵⁶²⁶²⁷²⁸,Lepage Patricia¹⁵²⁵,Boneca Ivo Gomperts¹²¹³,Ghiringhelli François³⁴²⁹,Zitvogel Laurence¹³⁰²

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale, U1015, Equipe labellisée Ligue Nationale Contre le Cancer, Institut Gustave Roussy, Villejuif, France.

2. Université Paris-Sud, Kremlin Bicêtre, France.

3. Institut National de la Santé et de la Recherche Médicale, U866, Centre Georges François Leclerc, Dijon, France.

4. Institut National de la Santé et de la Recherche Médicale, Group Avenir, Dijon, France.

5. Institut National de la Santé et de la Recherche Médicale, U848, Institut Gustave Roussy, Villejuif, France.

6. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.

7. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

8. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A* STAR), Singapore.

9. Service de Microbiologie, Institut Gustave Roussy, Villejuif, France.

10. Lymphoid Tissue Development Unit, Institut Pasteur, Paris, France.

11. Nimalerie Centrale, Institut Pasteur, Paris, France.

12. Institut Pasteur, Unit Biology and Genetics of the Bacterial Cell Wall, Paris, France.

13. Institut National de la Santé et de la Recherche Médicale, Group Avenir, Paris, France.

14. Institut Pasteur, Collection de l’Institut Pasteur, Paris, France.

15. Institut National de la Recherche Agronomique, Micalis–UMR1319, 78350 Jouy-en-Josas, France.

16. Institut National de la Santé et de la Recherche Médicale U989, Université Paris Descartes, 75730 Paris, France.

17. Institut Gustave Roussy, IFR54, Villejuif, France.

18. Institut Gustave Roussy, Institut de Recherche en Cancérologie Intégrée de Villejuif (IRCIV), Laboratoire de Pathologie Expérimentale, Villejuif, France.

19. Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université UM2, Marseille, France.

20. Institut National de la Santé et de la Recherche Médicale, UMR 1104, Marseille, France.

21. Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, Marseille, France.

22. Assistance Publique des Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.

23. Laboratory of Molecular and Experimental Immunology and Neurogenetics, UMR 7355, CNRS-University of Orleans, Orleans, France.

24. University of Alabama at Birmingham, Birmingham, AL, USA.

25. AgroParisTech, Micalis–UMR1319, 78352 Jouy-en-Josas, France.

26. Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.

27. Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique–Hôpitaux de Paris, Paris, France.

28. Université Paris Descartes, Paris, France.

29. Faculté de Médecine, Université de Bourgogne, Dijon, France.

30. Centre d’Investigation Clinique Biothérapie CICBT 507, Institut Gustave Roussy, Villejuif, France.

Abstract

The Microbiota Makes for Good Therapy The gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given the important role our intestinal habitants play in metabolism—they may also modulate the efficacy of certain cancer therapeutics. Iida et al. (p. 967 ) evaluated the impact of the microbiota on the efficacy of an immunotherapy [CpG (the cytosine, guanosine, phosphodiester link) oligonucleotides] and oxaliplatin, a platinum compound used as a chemotherapeutic. Both therapies were reduced in efficacy in tumor-bearing mice that lacked microbiota, with the microbiota important for activating the innate immune response against the tumors. Viaud et al. (p. 971 ) found a similar effect of the microbiota on tumor-bearing mice treated with cyclophosphamide, but in this case it appeared that the microbiota promoted an adaptive immune response against the tumors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Interactions Between the Microbiota and the Immune System

2. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

3. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

4. The Role of Intestinal Microbiota in the Development and Severity of Chemotherapy-Induced Mucositis

5. Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans

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