Chemically induced proximity in biology and medicine-Reference-Cited by-同舟云学术

Chemically induced proximity in biology and medicine

Published:2018-03-09 Issue:6380 Volume:359 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Stanton Benjamin Z.¹²^ORCID,Chory Emma J.¹³^ORCID,Crabtree Gerald R.¹⁴^ORCID

Affiliation:

1. Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

3. Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

4. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Regulating molecule proximity The physical distance, or proximity, between molecules often directs biological events. The development of membrane-permeable small molecules that reversibly regulate proximity has enabled advances in fields such as synthetic biology, signal transduction, transcription, protein degradation, epigenetic memory, and chromatin dynamics. This “induced proximity” can also be applied to the development of new therapeutics. Stanton et al. review the wide range of advances and speculate on future applications of this fundamental approach. Science , this issue p. eaao5902

Funder

National Institutes of Health

Howard Hughes Medical Institute

U.S. Department of Energy

National Cancer Institute

Simons Foundation Autism Research Initiative

Simons Foundation

NSF Office of the Director

Ruth L. Kirschstein National Research Service Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject