Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice-Reference-Cited by-同舟云学术

Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice

Published:2012-11-16 Issue:6109 Volume:338 Page:971-975
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hayashi Katsuhiko¹²³,Ogushi Sugako¹⁴,Kurimoto Kazuki¹⁵,Shimamoto So¹,Ohta Hiroshi¹⁵,Saitou Mitinori¹²⁵⁶

Affiliation:

1. Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

2. Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan.

3. Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST)/Precursory Research for Embryonic Science and Technology (PRESTO), Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

4. The Hakubi Center for Advanced Research, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8302, Japan.

5. JST, CREST/Exploratory Research for Advanced Technology (ERATO), Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

6. Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Abstract

Artificially Induced Oocytes In mice, male embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been shown to differentiate into primordial germ cell–like cells (PGCLCs) in vitro. Upon transplantation into testes, these PGCLCs can form fully functional sperm. Again working in mice, Hayashi et al. (p. 971 , published online 4 October) found that female ESCs and iPSCs can also differentiate into PGCLCs, which, when aggregated in reconstituted ovaries, exhibited epigenetic reprogramming and meiotic potential in vitro. Upon transplantation of the reconstituted ovaries under ovarian bursa, female PGCLCs developed into fully grown oocytes that contributed to healthy offspring upon in vitro maturation and fertilization.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.

1. Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

2. Global hypomethylation of the genome in XX embryonic stem cells

3. Epigenetic events in mammalian germ-cell development: reprogramming and beyond

4. A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Prdm1-mVenus and Dppa3-ECFP double transgenic reporter

5. Mouse Offspring Derived from Fetal Ovaries or Reaggregates Which were Cultured and Transplanted into Adult Females

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