N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription-Reference-Cited by-同舟云学术

N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Published:2020-01-31 Issue:6477 Volume:367 Page:580-586
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Liu Jun¹²^ORCID,Dou Xiaoyang¹²^ORCID,Chen Chuanyuan³⁴^ORCID,Chen Chuan⁵,Liu Chang¹²^ORCID,Xu Meng Michelle⁶,Zhao Siqi³⁴,Shen Bin⁷^ORCID,Gao Yawei⁵^ORCID,Han Dali³⁴⁸⁹^ORCID,He Chuan¹²¹⁰^ORCID

Affiliation:

1. Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.

2. Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.

3. Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.

4. College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China.

5. Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200120, China.

6. Department of Basic Medical Sciences, School of Medicine, Institute for Immunology, Beijing Key Laboratory for Immunological Research on Chronic Diseases, THU-PKU Center for Life Sciences, Tsinghua University, Beijing 100084. China.

7. State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 211166, China.

8. China National Center for Bioinformation, Beijing 100101, China.

9. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.

10. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.

Abstract

A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m 6 A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m 6 A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. Science , this issue p. 580

Funder

National Science Foundation

National Institutes of Health

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.

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