An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

Author:

Stenger Steffen1,Hanson Dennis A.1,Teitelbaum Rachel1,Dewan Puneet1,Niazi Kayvan R.1,Froelich Christopher J.1,Ganz Tomas1,Thoma-Uszynski Sybille1,Melián Agustı́n1,Bogdan Christian1,Porcelli Steven A.1,Bloom Barry R.1,Krensky Alan M.1,Modlin Robert L.1

Affiliation:

1. S. Stenger, P. Dewan, K. R. Niazi, T. Ganz, S. Thoma-Uszynski, R. L. Modlin, Divisions of Dermatology and Pulmonary Medicine, Department of Medicine, Department of Microbiology and Immunology and the Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA. D. A. Hanson and A. M. Krensky, Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA. R. Teitelbaum and B. R. Bloom, Howard Hughes Medical Institute,...

Abstract

Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis , altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis . The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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