A global view of meiotic double-strand break end resection

Abstract

Recombination revealed by mapping tails Meiosis is a specialized double cell division that generates haploid gametes from diploid parent cells. Meiotic recombination between homologous chromosomes ensures the proper segregation of chromosomes to the daughter cells. Mimitou et al. carried out a genome-wide survey of resection of the ends of DNA double strand breaks in yeast. Resection generates single-stranded tails that are vital for meiotic recombination. The Tel1 kinase promoted initiation of resection. Nucleosomes, which normally package DNA, needed to be disassembled to allow rapid and efficient resection. Science, this issue p. 40