Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Author:

Jeltsch Michael123,Kaipainen Arja123,Joukov Vladimir123,Meng Xiaojuan123,Lakso Merja123,Rauvala Heikki123,Swartz Melody123,Fukumura Dai123,Jain Rakesh K.123,Alitalo Kari123

Affiliation:

1. M. Jeltsch, A. Kaipainen, V. Joukov, K. Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, Post Office Box 21 (Haartmaninkatu 3), University of Helsinki, SF-00014 Helsinki, Finland.

2. X. Meng, M. Lakso, H. Rauvala, Biotechnology Institute, 00014 University of Helsinki, Helsinki, Finland.

3. M. Swartz, D. Fukumura, R. K. Jain, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Abstract

No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but not vascular, endothelial proliferation and vessel enlargement. Thus, VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis. VEGF-C may play a role in disorders involving the lymphatic system and may be of potential use in therapeutic lymphangiogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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