The Organization of Replication and Transcription

Author:

Cook Peter R.1

Affiliation:

1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Abstract

Models for replication and transcription often display polymerases that track like locomotives along their DNA templates. However, recent evidence supports an alternative model in which DNA and RNA polymerases are immobilized by attachment to larger structures, where they reel in their templates and extrude newly made nucleic acids. These polymerases do not act independently; they are concentrated in discrete “factories,” where they work together on many different templates. Evidence for models involving tracking and immobile polymerases is reviewed.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference108 articles.

1. B. Alberts et al. Molecular Biology of the Cell (Garland New York ed. 3 1994); H. Lodish et al. Molecular Cell Biology (Scientific American Books New York ed. 3 1995).

2. A. Kornberg and T. A. Baker DNA Replication (Freeman New York ed. 3 1992).

3. Recent evidence suggests that eukaryotic RNA polymerase II [

4. BASIC MECHANISMS OF TRANSCRIPT ELONGATION AND ITS REGULATION

5. ] associates with other factors and “mediators” [

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