NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice-Reference-Cited by-同舟云学术

NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

Published:2016-06-17 Issue:6292 Volume:352 Page:1436-1443
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Hongbo¹,Ryu Dongryeol¹,Wu Yibo²,Gariani Karim¹,Wang Xu¹,Luan Peiling¹,D’Amico Davide¹,Ropelle Eduardo R.¹³,Lutolf Matthias P.⁴,Aebersold Ruedi²⁵,Schoonjans Kristina⁶,Menzies Keir J.¹⁷,Auwerx Johan¹

Affiliation:

1. Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

2. Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.

3. Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.

4. Laboratory of Stem Cell Bioengineering, EPFL, 1015 Lausanne, Switzerland.

5. Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.

6. Metabolic Signaling, EPFL, 1015 Lausanne, Switzerland.

7. Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute, 451 Smyth Road, K1H 8M5 Ottawa, Ontario, Canada.

Abstract

A dietary supplement protects aging muscle The oxidized form of cellular nicotinamide adenine dinucleotide (NAD + ) is critical for mitochondrial function, and its supplementation can lead to increased longevity. Zhang et al. found that feeding the NAD + precursor nicotinamide riboside (NR) to aging mice protected them from muscle degeneration (see the Perspective by Guarente). NR treatment enhanced muscle function and also protected mice from the loss of muscle stem cells. The treatment was similarly protective of neural and melanocyte stem cells, which may have contributed to the extended life span of the NR-treated animals. Science , this issue p. 1436 ; see also p. 1396

Funder

University of Ottawa

Heart and Stroke Foundation of Canada

NIH

Krebsforschung Schweiz/SwissCancerLeague

Systems X

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference54 articles.