Identification of a Chemokine Receptor Encoded by Human Cytomegalovirus as a Cofactor for HIV-1 Entry-Reference-Cited by-同舟云学术

Identification of a Chemokine Receptor Encoded by Human Cytomegalovirus as a Cofactor for HIV-1 Entry

Published:1997-06-20 Issue:5320 Volume:276 Page:1874-1878
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pleskoff Olivier¹²,Tréboute Carole¹²,Brelot Anne¹²,Heveker Nikolaus¹²,Seman Michel¹²,Alizon Marc¹²

Affiliation:

1. O. Pleskoff, C. Tréboute, A. Brelot, N. Heveker, M. Alizon, Inserm U.332, Institut Cochin de Génétique Moléculaire, 22 rue Méchain, 75014 Paris, France.

2. M. Seman, Laboratoire d'Immunodifférenciation, UniversitéParis 7, 75005 Paris, France.

Abstract

The human cytomegalovirus encodes a β-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus–type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line–adapted HIV-1 for which CXCR4 was an entry cofactor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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