Global DNA Demethylation During Mouse Erythropoiesis in Vivo-Reference-Cited by-同舟云学术

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Global DNA Demethylation During Mouse Erythropoiesis in Vivo

Published:2011-11-11 Issue:6057 Volume:334 Page:799-802
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shearstone Jeffrey R.¹,Pop Ramona¹,Bock Christoph²³⁴,Boyle Patrick²,Meissner Alexander²³⁴,Socolovsky Merav¹

Affiliation:

1. Department of Pediatrics and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

2. Broad Institute, Cambridge, MA 02142, USA.

3. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

4. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Abstract

Erythroblasts undergoing differentiation into red cells lose one-third of DNA methylation marks at nearly all genomic loci.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression

2. Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis

3. LUMA (LUminometric Methylation Assay)—A high throughput method to the analysis of genomic DNA methylation

4. Direct detection of methylated cytosine in DNA by use of the restriction enzyme Mspl

5. Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions

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