Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak-Reference-Cited by-同舟云学术

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Published:2016-03-04 Issue:6277 Volume:351 Page:1078-1083
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bornholdt Zachary A.¹,Turner Hannah L.²,Murin Charles D.¹²,Li Wen³,Sok Devin¹,Souders Colby A.⁴,Piper Ashley E.⁵,Goff Arthur⁵,Shamblin Joshua D.⁵,Wollen Suzanne E.⁵,Sprague Thomas R.⁵,Fusco Marnie L.¹,Pommert Kathleen B. J.¹,Cavacini Lisa A.⁴,Smith Heidi L.⁴,Klempner Mark⁴,Reimann Keith A.⁴,Krauland Eric³,Gerngross Tillman U.³,Wittrup Karl D.³,Saphire Erica Ollmann¹,Burton Dennis R.¹⁶,Glass Pamela J.⁵,Ward Andrew B.²,Walker Laura M.³

Affiliation:

1. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. Adimab, Lebanon, NH 03766, USA.

4. MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.

5. U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

6. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02142, USA.

Abstract

Profiling the antibody response to Ebola The recent Ebola virus outbreak in West Africa illustrates the need not only for a vaccine but for potential therapies, too. One promising therapy is monoclonal antibodies that target Ebola's membrane-anchored glycoprotein (GP). Bornholdt et al. isolated and characterized 349 antibodies from a survivor of the 2014 outbreak. A large fraction showed some neutralizing activity and several were quite potent. Structural analysis revealed an important site of vulnerability on the membrane stalk region of GP. Antibodies targeting this area were therapeutically effective in Ebola virus–infected mice. Science , this issue p. 1078

Funder

U.S. NIH

Defense Advanced Research Projects Agency

HIV/AIDS Vaccine Immunology and Immunogen Discovery

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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