Genome Sequence of the Radioresistant Bacterium
Deinococcus radiodurans
R1
Author:
White Owen1, Eisen Jonathan A.1, Heidelberg John F.1, Hickey Erin K.1, Peterson Jeremy D.1, Dodson Robert J.1, Haft Daniel H.1, Gwinn Michelle L.1, Nelson William C.1, Richardson Delwood L.1, Moffat Kelly S.1, Qin Haiying1, Jiang Lingxia1, Pamphile Wanda1, Crosby Marie1, Shen Mian1, Vamathevan Jessica J.1, Lam Peter1, McDonald Lisa1, Utterback Terry1, Zalewski Celeste1, Makarova Kira S.2, Aravind L.2, Daly Michael J.3, Minton Kenneth W.3, Fleischmann Robert D.1, Ketchum Karen A.1, Nelson Karen E.1, Salzberg Steven1, Smith Hamilton O.1, Craig J., Venter 1, Fraser Claire M.1
Affiliation:
1. The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. 2. National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA. 3. Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Abstract
The complete genome sequence of the radiation-resistant bacterium
Deinococcus radiodurans
R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of
D. radiodurans
to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified.
Deinococcus radiodurans
represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
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