Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity-Reference-Cited by-同舟云学术

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

Published:2010-01-08 Issue:5962 Volume:327 Page:213-216
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Maze Ian¹,Covington Herbert E.¹,Dietz David M.¹,LaPlant Quincey¹²,Renthal William²,Russo Scott J.¹,Mechanic Max²,Mouzon Ezekiell¹,Neve Rachael L.³,Haggarty Stephen J.⁴⁵,Ren Yanhua¹,Sampath Srihari C.⁶,Hurd Yasmin L.¹,Greengard Paul⁷,Tarakhovsky Alexander⁶,Schaefer Anne⁷,Nestler Eric J.¹

Affiliation:

1. Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.

2. Departments of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.

3. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

4. Psychiatric and Neurodevelopmental Genetics Unit and Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.

5. Stanley Center for Psychiatric Research, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.

6. Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY, USA.

7. Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, USA.

Abstract

Cocaine Addiction and Histone Methylation Long-lasting behavioral syndromes associated with chronic cocaine exposure may result from dysregulation of the global transcriptional machinery. Maze et al. (p. 213 ) observed that histone lysine methylation in the nucleus accumbens plays a critical role in mediating the regulation of gene expression in response to repeated cocaine self-administration. Chronic cocaine was linked to overall reductions in dimethylation of lysine 9 of histone 3 (H3K9) in this brain region. Repressing H3K9 after chronic cocaine administration facilitated reward-related changes in behavior. The authors identifed the methyltransferase G9a as an essential mediator and an important regulator of dendritic spine plasticity. Downregulation of G9a was linked to the transcription factor ΔFosB.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

1. Structural plasticity associated with exposure to drugs of abuse

2. NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

3. Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum

4. Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

5. FosB Mediates Epigenetic Desensitization of the c-fos Gene After Chronic Amphetamine Exposure

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