Plant “helper” immune receptors are Ca 2+ -permeable nonselective cation channels-Reference-Cited by-同舟云学术

Plant “helper” immune receptors are Ca 2+ -permeable nonselective cation channels

Published:2021-07-23 Issue:6553 Volume:373 Page:420-425
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jacob Pierre¹^ORCID,Kim Nak Hyun¹^ORCID,Wu Feihua²³^ORCID,El-Kasmi Farid⁴^ORCID,Chi Yuan²^ORCID,Walton William G.⁵^ORCID,Furzer Oliver J.¹^ORCID,Lietzan Adam D.⁶^ORCID,Sunil Sruthi⁴,Kempthorn Korina¹,Redinbo Matthew R.⁵^ORCID,Pei Zhen-Ming²^ORCID,Wan Li¹⁷^ORCID,Dangl Jeffery L.¹^ORCID

Affiliation:

1. Department of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Department of Biology, Duke University, Durham, NC 27708, USA.

3. Department of Horticulture, Foshan University, Foshan, China.

4. Department of Plant Physiology, Centre of Plant Molecular Biology (ZMBP), University of Tübingen, Tübingen, Germany.

5. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

7. National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.

Abstract

Calcium signaling for host cell death In response to microbial pathogens, some plants kill off their own cells to limit further spread of infection. The Toll/Interleukin-1 receptor/Resistance class of nucleotide-binding leucine-rich repeat receptors (known as TNLs) function in plants as immune receptors. These TNLs work together with a dedicated set of helper proteins. Jacob et al. reveal the structure of one of these helpers known as NRG1 (N REQUIREMENT GENE 1). The structure resembles a known animal cation channel. The authors demonstrate that helper NLRs directly control calcium ion influx to initiate host cell death, providing a mechanism for TNL outputs. Science , abg7917, this issue p. 420

Funder

National Science Foundation

National Institutes of Health

Howard Hughes Medical Institute

Lineberger Comprehensive Cancer Center, University of North Carolina

Deutsche Forschungsgemeinschaft

National Research Foundation of Korea

University of Tübingen core funding

Reinhard Frank Stiftung

National Key Laboratory of Plant Molecular Genetics

Publisher

American Association for the Advancement of Science (AAAS)