Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids
Author:
Affiliation:
1. Department of Otolaryngology–Head and Neck Surgery, Head and Neck Cancer Research Division,
2. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Abstract
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference25 articles.
1. Mammalian mitochondrial genetics: heredity, heteroplasmy and disease
2. MITOMAP: A Human Mitochondrial Genome Database Center for Molecular Medicine Emory University Atlanta GA (www.gen.emory.edu/mitomap.html).
3. Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells
4. Somatic mutations of the mitochondrial genome in human colorectal tumours
5. Paired normal and tumor specimens along with blood and bodily fluids were collected after surgical resections with prior consent from patients in the Johns Hopkins University Hospital. Tumor specimens were frozen and microdissected on a cryostat so that the tumor samples contained greater than 70% neoplastic cells. DNA from tumor sections was digested with 1% SDS/Proteinase K extracted by phenol-chloroform and ethanol precipitated. Control DNAs from peripheral lymphocytes matched normal tissues urine saliva and BAL fluid were processed in the same manner as described in (12).
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