Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites-Reference-Cited by-同舟云学术

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

Published:2020-10-30 Issue:6516 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Guo Hao¹^ORCID,Chou Wei-Chun¹²^ORCID,Lai Yunjia³^ORCID,Liang Kaixin¹⁴^ORCID,Tam Jason W.¹^ORCID,Brickey W. June¹⁵^ORCID,Chen Liang¹²⁵^ORCID,Montgomery Nathan D.¹⁶^ORCID,Li Xin¹^ORCID,Bohannon Lauren M.⁷^ORCID,Sung Anthony D.⁷^ORCID,Chao Nelson J.⁷^ORCID,Peled Jonathan U.⁸⁹^ORCID,Gomes Antonio L. C.⁸⁹^ORCID,van den Brink Marcel R. M.⁸⁹^ORCID,French Matthew J.¹⁰^ORCID,Macintyre Andrew N.¹⁰^ORCID,Sempowski Gregory D.¹⁰^ORCID,Tan Xianming¹^ORCID,Sartor R. Balfour¹¹,Lu Kun³^ORCID,Ting Jenny P. Y.¹²⁵^ORCID

Affiliation:

1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

2. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

3. Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

4. School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

5. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

6. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

7. Division of Hematologic Malignancies and Cellular Therapy/BMT, Department of Medicine, Duke University, Durham, NC, USA.

8. Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

9. Weill Cornell Medical College, New York, NY, USA.

10. Duke Human Vaccine Institute, Duke University, Durham, NC, USA.

11. Center for Gastrointestinal Biology and Disease, Department of Medicine, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Abstract

Radioprotective bacteria A common symptom of radiation treatment for cancer is gastrointestinal disruption. The damage caused can become so severe and debilitating that it interrupts treatment. Guo et al. noticed that mice surviving experimental radiation exposure had distinctive taxonomic representation in their gut microbiota. A similar correlation was also observed in a small group of human subjects. Further experiments in mice revealed that some strains of bacteria produced high levels of short-chain fatty acids, which seemed to be dampening inflammatory responses and alleviating the damage caused by reactive oxygen species released by the radiation. A metabolomics analysis also implicated a role for tryptophan metabolic pathways in radiation survivorship. Science , this issue p. eaay9097

Funder

National Institutes of Health

National Institute on Aging

NIH Office of the Director

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Multiple Sclerosis Society

National Institute of Environmental Health Sciences

Publisher

American Association for the Advancement of Science (AAAS)