Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm-Reference-Cited by-同舟云学术

Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm

Published:2019-03-22 Issue:6433 Volume:363 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hinch Anjali Gupta¹^ORCID,Zhang Gang¹^ORCID,Becker Philipp W.¹^ORCID,Moralli Daniela¹^ORCID,Hinch Robert¹²^ORCID,Davies Benjamin¹^ORCID,Bowden Rory¹^ORCID,Donnelly Peter¹³^ORCID

Affiliation:

1. Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

2. Big Data Institute, University of Oxford, Oxford, UK.

3. Department of Statistics, University of Oxford, Oxford, UK.

Abstract

Sequencing and the single sperm During meiosis, homologous chromosomes undergo doublestrand breaks in DNA that can cross over, shuffling genetic material. However, not every double-strand break resolves in a crossover event. Hinch et al. wanted to determine the rules governing DNA recombination. They developed a method to sequence individual mouse sperm and applied it to mice carrying two different alleles of a protein involved in mammalian crossovers. A high-resolution genetic map revealed the relationships between the distribution of crossovers, proteins involved in recombination, and specific factors determining whether a double-strand break becomes a crossover. Science , this issue p. eaau8861

Funder

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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