Precise T cell recognition programs designed by transcriptionally linking multiple receptors-Reference-Cited by-同舟云学术

Precise T cell recognition programs designed by transcriptionally linking multiple receptors

Published:2020-11-27 Issue:6520 Volume:370 Page:1099-1104
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Williams Jasper Z.¹²³^ORCID,Allen Greg M.¹²³⁴^ORCID,Shah Devan¹²³,Sterin Igal S.¹²³^ORCID,Kim Ki H.¹²³^ORCID,Garcia Vivian P.¹²³^ORCID,Shavey Gavin E.¹²³,Yu Wei¹²³,Puig-Saus Cristina⁵^ORCID,Tsoi Jennifer⁵^ORCID,Ribas Antoni⁵^ORCID,Roybal Kole T.¹²³^ORCID,Lim Wendell A.¹²³⁶^ORCID

Affiliation:

1. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

3. Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

4. Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.

5. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

6. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

A logic to cell-cell recognition There has been exciting progress in the field of cancer immunotherapy, which harnesses a patient's own immune system to kill cancer cells. However, achieving precise recognition of cancer cells remains challenging. Cells engineered with synthetic Notch (synNotch) receptors bind to specific antigens, and binding induces the expression of defined genes. Williams et al. used synNotch modules as transcriptional connectors that daisy-chain together multiple receptors. They engineered T cells that can recognize up to three target antigens expressed on or inside cancer cells and integrated these inputs to achieve NOT, AND, and OR logic. The engineered cells achieved precise recognition of targeted cancer cells. Science , this issue p. 1099

Funder

National Institutes of Health

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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