Lifelong persistence of nuclear RNAs in the mouse brain-Reference-Cited by-同舟云学术

Lifelong persistence of nuclear RNAs in the mouse brain

Published:2024-04-05 Issue:6691 Volume:384 Page:53-59
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zocher Sara¹^ORCID,McCloskey Asako²³^ORCID,Karasinsky Anne¹,Schulte Roberta²,Friedrich Ulrike⁴⁵⁶^ORCID,Lesche Mathias⁴^ORCID,Rund Nicole¹,Gage Fred H.⁷^ORCID,Hetzer Martin W.⁸^ORCID,Toda Tomohisa¹⁹^ORCID

Affiliation:

1. Nuclear Architecture in Neural Plasticity and Aging, German Center for Neurodegenerative Diseases (DZNE), Dresden 01307, Germany.

2. Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

3. Kura Oncology, Inc., San Diego, CA 92121, USA.

4. DRESDEN-concept Genome Center, Technology Platform at the Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Fetscherstr. 105, Dresden 01307, Germany.

5. German Center for Diabetes Research (DZD e.V.), 85764 Neuherberg, Germany.

6. Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

7. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

8. Institute of Science and Technology Austria (ISTA), 3400 Klosterneuburg, Austria.

9. Laboratory of Neural Epigenomics, Institute of Medical Physics and Micro-tissue Engineering, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91054, Germany.

Abstract

Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type–specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.adf3481

Reference35 articles.

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