Large-Scale Sequence Analysis of Avian Influenza Isolates-Reference-Cited by-同舟云学术

Large-Scale Sequence Analysis of Avian Influenza Isolates

Published:2006-03-17 Issue:5767 Volume:311 Page:1576-1580
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Obenauer John C.¹²³⁴,Denson Jackie¹²³⁴,Mehta Perdeep K.¹²³⁴,Su Xiaoping¹²³⁴,Mukatira Suraj¹²³⁴,Finkelstein David B.¹²³⁴,Xu Xiequn¹²³⁴,Wang Jinhua¹²³⁴,Ma Jing¹²³⁴,Fan Yiping¹²³⁴,Rakestraw Karen M.¹²³⁴,Webster Robert G.¹²³⁴,Hoffmann Erich¹²³⁴,Krauss Scott¹²³⁴,Zheng Jie¹²³⁴,Zhang Ziwei¹²³⁴,Naeve Clayton W.¹²³⁴

Affiliation:

1. Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

2. Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

3. Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

4. Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Abstract

The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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