A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction-Reference-Cited by-同舟云学术

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

Published:2007-06-08 Issue:5830 Volume:316 Page:1491-1493
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Helgadottir Anna¹²³⁴⁵,Thorleifsson Gudmar¹²³⁴⁵,Manolescu Andrei¹²³⁴⁵,Gretarsdottir Solveig¹²³⁴⁵,Blondal Thorarinn¹²³⁴⁵,Jonasdottir Aslaug¹²³⁴⁵,Jonasdottir Adalbjorg¹²³⁴⁵,Sigurdsson Asgeir¹²³⁴⁵,Baker Adam¹²³⁴⁵,Palsson Arnar¹²³⁴⁵,Masson Gisli¹²³⁴⁵,Gudbjartsson Daniel F.¹²³⁴⁵,Magnusson Kristinn P.¹²³⁴⁵,Andersen Karl¹²³⁴⁵,Levey Allan I.¹²³⁴⁵,Backman Valgerdur M.¹²³⁴⁵,Matthiasdottir Sigurborg¹²³⁴⁵,Jonsdottir Thorbjorg¹²³⁴⁵,Palsson Stefan¹²³⁴⁵,Einarsdottir Helga¹²³⁴⁵,Gunnarsdottir Steinunn¹²³⁴⁵,Gylfason Arnaldur¹²³⁴⁵,Vaccarino Viola¹²³⁴⁵,Hooper W. Craig¹²³⁴⁵,Reilly Muredach P.¹²³⁴⁵,Granger Christopher B.¹²³⁴⁵,Austin Harland¹²³⁴⁵,Rader Daniel J.¹²³⁴⁵,Shah Svati H.¹²³⁴⁵,Quyyumi Arshed A.¹²³⁴⁵,Gulcher Jeffrey R.¹²³⁴⁵,Thorgeirsson Gudmundur¹²³⁴⁵,Thorsteinsdottir Unnur¹²³⁴⁵,Kong Augustine¹²³⁴⁵,Stefansson Kari¹²³⁴⁵

Affiliation:

1. deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.

2. Landspitali University Hospital, Reykjavik, Iceland.

3. Emory University School of Medicine, Atlanta, GA 30322, USA.

4. University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

5. Duke University School of Medicine, Durham, NC 27710, USA.

Abstract

The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B , was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference12 articles.

1. T. Thom et al., Circulation113, e85 (2006).

2. Materials and methods are available as supporting material on Science Online.

3. Genomic Control for Association Studies

4. N. Mantel, W. Haenszel, J. Natl. Cancer Inst.22, 719 (1959).

5. Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins

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