Dendritic Cell Stimulation by Mycobacterial Hsp70 Is Mediated Through CCR5-Reference-Cited by-同舟云学术

Dendritic Cell Stimulation by Mycobacterial Hsp70 Is Mediated Through CCR5

Published:2006-10-20 Issue:5798 Volume:314 Page:454-458
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Floto R. Andres¹²³⁴⁵,MacAry Paul A.¹²³⁴⁵,Boname Jessica M.¹²³⁴⁵,Mien Tan Suet¹²³⁴⁵,Kampmann Beate¹²³⁴⁵,Hair James R.¹²³⁴⁵,Huey Oh Seen¹²³⁴⁵,Houben Edith N. G.¹²³⁴⁵,Pieters Jean¹²³⁴⁵,Day Cheryl¹²³⁴⁵,Oehlmann Wulf¹²³⁴⁵,Singh Mahavir¹²³⁴⁵,Smith Kenneth G. C.¹²³⁴⁵,Lehner Paul J.¹²³⁴⁵

Affiliation:

1. Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

2. Immunology Program, Department of Microbiology, The Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.

3. Division of Molecular and Cell Biology, School of Biological Sciences, Nanyang Technological University, Singapore.

4. Department of Paediatrics and Wellcome Centre for Clinical Tropical Medicine, Imperial College London, UK.

5. Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.

Abstract

An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse formation between dendritic cells and T cells, and the generation of effector immune responses. Thus, CCR5 acts as a pattern-recognition receptor for myHsp70, which may have implications for both the pathophysiology of tuberculosis and the use of myHsps in tumor-directed immunotherapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

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