Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury-Reference-Cited by-同舟云学术

Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury

Published:2021-09-10 Issue:6560 Volume:373 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Holden Stephanie S.¹²³⁴⁵^ORCID,Grandi Fiorella C.²³⁶⁴^ORCID,Aboubakr Oumaima²⁴^ORCID,Higashikubo Bryan²⁴,Cho Frances S.¹²³⁶⁴^ORCID,Chang Andrew H.²⁴^ORCID,Forero Alejandro Osorio⁶⁷^ORCID,Morningstar Allison R.²⁴^ORCID,Mathur Vidhu²⁸,Kuhn Logan J.²⁸^ORCID,Suri Poojan²⁸,Sankaranarayanan Sethu²⁸^ORCID,Andrews-Zwilling Yaisa²⁸,Tenner Andrea J.¹⁴^ORCID,Luthi Anita⁶⁷^ORCID,Aronica Eleonora³⁷⁵^ORCID,Corces M. Ryan²³⁶⁴^ORCID,Yednock Ted²⁸^ORCID,Paz Jeanne T.¹²³⁸⁵^ORCID

Affiliation:

1. Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.

3. Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.

4. Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

5. Stichting Epilepsie Instellingen Nederland (SEIN), 2103 SW Heemstede, Netherlands.

6. Department of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, Switzerland.

7. Department of Neuropathology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

8. Annexon Biosciences, South San Francisco, CA 94080, USA.

Abstract

Neuroinflammation after brain injury Traumatic brain injury affects millions of people every year and is a major cause of disability worldwide. Most of the maladaptive outcomes develop months or years later and are thought to be caused by secondary injuries that are indirect and long-term effects after the initial impact. Holden et al . found that secondary and chronic neuroinflammation and neurodegeneration are caused by the C1q molecule, a mediator of the complement pathway. C1q is responsible for chronic inflammation and secondary neuronal loss specifically in the cortico-thalamo-cortical circuit. Traumatic brain injury also leads to altered brain states that are caused by the C1q complement pathway. —PRS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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