Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel

Author:

Prunas Ottavia12ORCID,Warren Joshua L.23ORCID,Crawford Forrest W.23456ORCID,Gazit Sivan7ORCID,Patalon Tal7ORCID,Weinberger Daniel M.12ORCID,Pitzer Virginia E.12ORCID

Affiliation:

1. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.

2. Public Health Modeling Unit, Yale School of Public Health, Yale University, New Haven, CT, USA.

3. Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.

4. Department of Statistics and Data Science, Yale School of Public Health, Yale University, New Haven, CT, USA.

5. Department of Ecology and Evolutionary Biology, Yale School of Public Health, Yale University, New Haven, CT, USA.

6. Yale School of Management, Yale University, New Haven, CT, USA.

7. Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.

Abstract

The effectiveness of vaccines against COVID-19 on the individual level is well established. However, few studies have examined vaccine effectiveness against transmission. We used a chain binomial model to estimate the effectiveness of vaccination with BNT162b2 [Pfizer-BioNTech messenger RNA (mRNA)-based vaccine] against household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Israel before and after emergence of the B.1.617.2 (Delta) variant. Vaccination reduced susceptibility to infection by 89.4% [95% confidence interval (CI): 88.7 to 90.0%], whereas vaccine effectiveness against infectiousness given infection was 23.0% (95% CI: −11.3 to 46.7%) during days 10 to 90 after the second dose, before 1 June 2021. Total vaccine effectiveness was 91.8% (95% CI: 88.1 to 94.3%). However, vaccine effectiveness is reduced over time as a result of the combined effect of waning of immunity and emergence of the Delta variant.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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