Serial Femtosecond Crystallography of G Protein–Coupled Receptors-Reference-Cited by-同舟云学术

Serial Femtosecond Crystallography of G Protein–Coupled Receptors

Published:2013-12-20 Issue:6165 Volume:342 Page:1521-1524
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Liu Wei¹,Wacker Daniel¹,Gati Cornelius²,Han Gye Won¹,James Daniel³,Wang Dingjie³,Nelson Garrett³,Weierstall Uwe³,Katritch Vsevolod¹,Barty Anton²,Zatsepin Nadia A.³,Li Dianfan⁴,Messerschmidt Marc⁵,Boutet Sébastien⁵,Williams Garth J.⁵,Koglin Jason E.⁵,Seibert M. Marvin⁵⁶,Wang Chong¹,Shah Syed T. A.⁴,Basu Shibom⁷,Fromme Raimund⁷,Kupitz Christopher⁷,Rendek Kimberley N.⁷,Grotjohann Ingo⁷,Fromme Petra⁷,Kirian Richard A.²³,Beyerlein Kenneth R.²,White Thomas A.²,Chapman Henry N.²⁸⁹,Caffrey Martin⁴,Spence John C. H.³,Stevens Raymond C.¹,Cherezov Vadim¹

Affiliation:

1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Center for Free Electron Laser Science, Deutsches Elektronen-Synchrotron, 22607 Hamburg, Germany.

3. Department of Physics, Arizona State University, Tempe, AZ 85287, USA.

4. School of Medicine and School of Biochemistry and Immunology, Trinity College, Dublin, Dublin 2, Ireland.

5. SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.

6. Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Husargatan 3, Box 596, SE-751 24 Uppsala, Sweden.

7. Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.

8. Department of Physics, University of Hamburg, 22761 Hamburg, Germany.

9. Center for Ultrafast Imaging, 22607 Hamburg, Germany.

Abstract

G Structures G protein–coupled receptors (GPCRs) are eukaryotic membrane proteins that have a central role in cellular communication and have become key drug targets. To overcome the difficulties of growing GPCRs crystals, Liu et al. (p. 1521 ) used an x-ray free-electron laser to determine a high-resolution structure of the serotonin receptor from microcrystals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

2. Structure of a nanobody-stabilized active state of the β2 adrenoceptor

3. Structure-Function of the G Protein–Coupled Receptor Superfamily

4. Molecular signatures of G-protein-coupled receptors

5. Restructuring G-Protein- Coupled Receptor Activation

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