Hedgehog Signaling: A Tale of Two Lipids-Reference-Cited by-同舟云学术

Hedgehog Signaling: A Tale of Two Lipids

Published:2001-11-30 Issue:5548 Volume:294 Page:1879-1881
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ingham Philip W.¹

Affiliation:

1. Medical Research Council (MRC) Intercellular Signalling Group, Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK.

Abstract

Hedgehog proteins constitute one of the major classes of intercellular signals that control inductive interactions during animal development. These proteins undergo unusual lipid modifications and signal through an unconventional transmembrane protein receptor that is characterized by a sequence motif implicated in sterol sensing. Recent studies suggest that the lipid adducts regulate the range and potency of the signals, whereas the sterol-sensing domain is essential for receptor activity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

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4. Z. Chamoun et al. Science 293 2080 (2001).

5. Lee J., Treisman J., Curr. Biol. 11, 1147 (2001).

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