Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice-Reference-Cited by-同舟云学术

Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice

Published:2003-11-14 Issue:5648 Volume:302 Page:1223-1227
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kodama Shohta¹,Kühtreiber Willem¹,Fujimura Satoshi¹,Dale Elizabeth A.¹,Faustman Denise L.¹

Affiliation:

1. Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 3602, Charlestown, MA 02129, USA.

Abstract

Nonobese diabetic (NOD) mice are a model for type 1 diabetes in humans. Treatment of NOD mice with end-stage disease by injection of donor splenocytes and complete Freund's adjuvant eliminates autoimmunity and permanently restores normoglycemia. The return of endogenous insulin secretion is accompanied by the reappearance of pancreatic β cells. We now show that live donor male or labeled splenocytes administered to diabetic NOD females contain cells that rapidly differentiate into islet and ductal epithelial cells within the pancreas. Treatment with irradiated splenocytes is also followed by islet regeneration, but at a slower rate. The islets generated in both instances are persistent, functional, and apparent in all NOD hosts with permanent disease reversal.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

2. G. Yan, Y. Fu, D. L. Faustman, J. Immunol.159, 3068 (1997).

3. An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

4. T. Hayashi, D. Faustman, Mol. Cell. Biol.19, 8646 (1999).

5. Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

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