Affiliation:
1. Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA.
Abstract
It's a Gas
Many antibiotics, including beta-lactams, aminoglycosides, and quinolones, kill bacteria (at least in part) by oxidative stress.
Gusarov
et al.
(p.
1380
) show that nitric oxide (NO) produced by bacterial NO synthases (bNOS) protects bacteria, including
Staphylococcus aureus
and
Bacillus anthracis
, against toxic agents they may encounter in the soil or in host organisms. Thus, bNOS activity is specifically induced in response to antibiotics and, in turn, activates the expression of another key antioxidant enzyme: superoxide dismutase. Hence, NO-mediated antibiotic resistance not only operates by direct chemical modification of toxic molecules, but also alleviates oxidative stress caused by naturally occurring antibiotics.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
333 articles.
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