Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Author:

Ridaura Vanessa K.1,Faith Jeremiah J.1,Rey Federico E.1,Cheng Jiye1,Duncan Alexis E.23,Kau Andrew L.1,Griffin Nicholas W.1,Lombard Vincent4,Henrissat Bernard45,Bain James R.678,Muehlbauer Michael J.6,Ilkayeva Olga6,Semenkovich Clay F.9,Funai Katsuhiko9,Hayashi David K.10,Lyle Barbara J.11,Martini Margaret C.11,Ursell Luke K.12,Clemente Jose C.12,Van Treuren William12,Walters William A.13,Knight Rob121415,Newgard Christopher B.678,Heath Andrew C.2,Gordon Jeffrey I.1

Affiliation:

1. Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

2. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. George Warren Brown School of Social Work, Washington University, St. Louis, MO 63130, USA.

4. Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, CNRS UMR 7257, 13288 Marseille, France.

5. Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.

6. Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.

7. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

8. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

9. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

10. Mondelez International, Glenview, IL 60025, USA.

11. Kraft Foods Group, Glenview, IL 60025, USA.

12. Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

13. Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

14. Biofrontiers Institute, University of Colorado, Boulder, CO 80309, USA.

15. Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.

Abstract

Transforming Fat to Thin How much does the microbiota influence the host's phenotype? Ridaura et al. ( 1241214 ; see the Perspective by Walker and Parkhill ) obtained uncultured fecal microbiota from twin pairs discordant for body mass and transplanted them into adult germ-free mice. It was discovered that adiposity is transmissible from human to mouse and that it was associated with changes in serum levels of branched-chain amino acids. Moreover, obese-phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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