Supramammillary regulation of locomotion and hippocampal activity-Reference-Cited by-同舟云学术

Supramammillary regulation of locomotion and hippocampal activity

Published:2021-12-17 Issue:6574 Volume:374 Page:1492-1496
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Farrell Jordan S.¹^ORCID,Lovett-Barron Matthew²³^ORCID,Klein Peter M.¹^ORCID,Sparks Fraser T.⁴⁵⁶^ORCID,Gschwind Tilo¹^ORCID,Ortiz Anna L.¹^ORCID,Ahanonu Biafra⁷⁸^ORCID,Bradbury Susanna²^ORCID,Terada Satoshi⁴⁵⁶^ORCID,Oijala Mikko¹,Hwaun Ernie¹^ORCID,Dudok Barna¹^ORCID,Szabo Gergely¹^ORCID,Schnitzer Mark J.⁷⁹^ORCID,Deisseroth Karl²⁹¹⁰^ORCID,Losonczy Attila⁴⁵⁶,Soltesz Ivan¹^ORCID

Affiliation:

1. Department of Neurosurgery, Stanford University, Stanford, CA, USA.

2. Department of Bioengineering, Stanford University, Stanford, CA, USA.

3. Neurobiology Section, Division of Biological Sciences, University of California, San Diego, CA, USA.

4. Department of Neuroscience, Columbia University, New York, NY, USA.

5. Kavli Institute for Brain Sciences, Columbia University, New York, NY, USA.

6. Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.

7. Departments of Biology and Applied Physics, Stanford University, Stanford, CA, USA.

8. Department of Anatomy, University of California, San Francisco, CA, USA.

9. Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.

10. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Abstract

Locomotion-related signals in the brain To calculate where we are in space, continuous knowledge of one’ s speed is necessary. How does the brain know how fast the body is traveling during locomotion? Using in vivo calcium imaging, electrophysiology, optogenetics, cell tracing, and histology, Farrell et al . identified neurons in the rodent supramammillary nucleus of the hypothalamus that encode future locomotor speed and potently drive locomotion when stimulated. Because these locomotor neurons have extensive axons in brain areas that support spatial navigation, this cell type distributes this information selectively to areas that require knowledge of speed. This nucleus is functionally positioned between input from a higher-order cognitive center and the downstream midbrain where locomotor nuclei reside. —PRS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference65 articles.

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