Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders-Reference-Cited by-同舟云学术

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

Published:2021-01-15 Issue:6526 Volume:371 Page:265-270
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Johmura Yoshikazu¹^ORCID,Yamanaka Takehiro¹^ORCID,Omori Satotaka¹^ORCID,Wang Teh-Wei¹^ORCID,Sugiura Yuki²^ORCID,Matsumoto Masaki³^ORCID,Suzuki Narumi¹^ORCID,Kumamoto Soichiro¹^ORCID,Yamaguchi Kiyoshi⁴^ORCID,Hatakeyama Seira⁴^ORCID,Takami Tomoyo³^ORCID,Yamaguchi Rui⁵^ORCID,Shimizu Eigo⁵^ORCID,Ikeda Kazutaka⁶^ORCID,Okahashi Nobuyuki⁶^ORCID,Mikawa Ryuta⁷^ORCID,Suematsu Makoto²^ORCID,Arita Makoto⁶⁸^ORCID,Sugimoto Masataka⁷^ORCID,Nakayama Keiichi I.³^ORCID,Furukawa Yoichi⁴^ORCID,Imoto Seiya⁹^ORCID,Nakanishi Makoto¹^ORCID

Affiliation:

1. Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

2. Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.

3. Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

4. Clinical Genome Research, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

5. Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

6. RIKEN Center for Integrative Medical Sciences, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

7. Research Institute, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi 474-8511, Japan.

8. Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Shibakoen, Minato-ku, Tokyo 105-0011, Japan.

9. Health Intelligence Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Abstract

Selective destruction of senescent cells Senescent cells are associated with a variety of age-related medical conditions and thus have been proposed as potential targets for therapy, but we do not yet have a full understanding of the underlying mechanisms. Johmura et al. used RNA interference to screen for enzymes essential to the survival of senescent cells (see the Perspective by Pan and Locasale). The authors identified a key role for glutamine metabolism, particularly the enzyme glutaminase 1, and demonstrated that inhibition of this pathway induced the death of senescent cells. Glutaminase targeting also ameliorated aging-related organ dysfunction and obesity-related disorders in mouse models, suggesting the potential therapeutic value of this approach. Science , this issue p. 265 ; see also p. 234

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Ono Medical Research Foundation

Princess Takamatsu Cancer Research Fund

Relay for Life Japan Cancer Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.

1. Cellular senescence in aging and age-related disease: from mechanisms to therapy