Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System-Reference-Cited by-同舟云学术

Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System

Published:2005-08-05 Issue:5736 Volume:309 Page:929-932
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Holt Ben F.¹²³⁴,Belkhadir Youssef¹²³⁴,Dangl Jeffery L.¹²³⁴

Affiliation:

1. Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.

2. Curriculum in Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

3. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

4. Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

Pathogen recognition by the plant immune system is governed by structurally related, polymorphic products of disease resistance ( R ) genes. RAR1 and/or SGT1b mediate the function of many R proteins. RAR1 controls preactivation R protein accumulation by an unknown mechanism. We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection. The balanced activities of RAR1 and SGT1, in concert with cytosolic HSP90, modulate preactivation R protein accumulation and signaling competence.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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