Affiliation:
1. Institute of Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms-Universität, Bonn, Germany.
Abstract
The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8
+
effector T cells (cross-presentation) or to CD4
+
T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8
+
or CD4
+
T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
506 articles.
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