A Screen for Genes Induced in the Suprachiasmatic Nucleus by Light-Reference-Cited by-同舟云学术

A Screen for Genes Induced in the Suprachiasmatic Nucleus by Light

Published:1998-03-06 Issue:5356 Volume:279 Page:1544-1547
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Morris Mary E.¹²,Viswanathan N.¹²,Kuhlman Sandra¹²,Davis Fred C.¹²,Weitz Charles J.¹²

Affiliation:

1. M. E. Morris and C. J. Weitz, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

2. N. Viswanathan, S. Kuhlman, F. C. Davis, Department of Biology, Northeastern University, Boston, MA 02115, USA.

Abstract

The mechanism by which mammalian circadian clocks are entrained to light-dark cycles is unknown. The clock that drives behavioral rhythms is located in the suprachiasmatic nucleus (SCN) of the brain, and entrainment is thought to require induction of genes in the SCN by light. A complementary DNA subtraction method based on genomic representational difference analysis was developed to identify such genes without making assumptions about their nature. Four clones corresponded to genes induced specifically in the SCN by light, all of which showed gating of induction by the circadian clock. Among these genes are c- fos and nur77 , two of the five early-response genes known to be induced in the SCN by light, and egr-3 , a zinc finger transcription factor not previously identified in the SCN. In contrast to known examples, egr-3 induction by light is restricted to the ventral SCN, a structure implicated in entrainment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. L. N. Edwards Cellular and Molecular Bases of Biological Clocks (Springer-Verlag Berlin 1988).

2. C. S. Pittendrigh and S. Daan J. Comp. Physiol. 106 291 (1976).

3. D. C. Klein R. Y. Moore S. M. Reppert Eds. Suprachiasmatic Nucleus: The Mind's Clock (Oxford Univ. Press New York 1991).

4. Moore R. Y., Klein D. C., Brain Res. 71, 17 (1974);

5. Klein D. C., Moore R. Y., ibid. 174, 245 (1979).

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