Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol-Reference-Cited by-同舟云学术

Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol

Published:1998-03-06 Issue:5356 Volume:279 Page:1541-1544
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Joyce Sebastian¹²³⁴,Woods Amina S.¹²³⁴,Yewdell Jonathan W.¹²³⁴,Bennink Jack R.¹²³⁴,De Silva A. Dharshan¹²³⁴,Boesteanu Alina¹²³⁴,Balk Steven P.¹²³⁴,Cotter Robert J.¹²³⁴,Brutkiewicz Randy R.¹²³⁴

Affiliation:

1. S. Joyce, A. D. De Silva, A. Boesteanu, Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033–0850, USA.

2. A. S. Woods and R. J. Cotter, Departments of Oncology and Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205–2185, USA.

3. J. W. Yewdell, J. R. Bennink, R. R. Brutkiewicz, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892–0440, USA.

4. S. P. Balk, Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen–like molecules, controls the differentiation and function of a T lymphocyte subset, NK1 + natural T cells, proposed to regulate immune responses. The CD1d1 crystal structure revealed a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were used to identify cellular glycosylphosphatidylinositol as a major natural ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through its phosphatidylinositol aspect with high affinity. Glycosylphosphatidylinositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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