Disruption of histone methylation in developing sperm impairs offspring health transgenerationally-Reference-Cited by-同舟云学术

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

Published:2015-11-06 Issue:6261 Volume:350 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Siklenka Keith¹,Erkek Serap²³,Godmann Maren⁴,Lambrot Romain⁴,McGraw Serge⁵,Lafleur Christine⁴,Cohen Tamara⁴,Xia Jianguo⁴⁶,Suderman Matthew⁷,Hallett Michael⁸,Trasler Jacquetta⁵⁹,Peters Antoine H. F. M.²³,Kimmins Sarah¹⁴

Affiliation:

1. Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

2. Friedrich Miescher Institute for Biomedical Research (FMI), CH-4058 Basel, Switzerland.

3. Faculty of Sciences, University of Basel, Basel, Switzerland.

4. Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada.

5. Department of Pediatrics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

6. Institute of Parasitology, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada.

7. MRC Integrative Epidemiology Unity, School of Social and Community Medicine, University of Bristol, Bristol, UK.

8. McGill Centre for Bioinformatics, School of Computer Science, Faculty of Science, McGill University, Montreal, Quebec, Canada.

9. Department of Human Genetics and Department of Pharmacology and Therapeutics, Research Institute of the McGill University Health Centre at the Montreal Children's Hospital, Montreal, Quebec, Canada.

Abstract

Generations affected by histone changes Parent and even grandparent environmental exposure can transmit adverse health effects to offspring. The mechanism of transmission is unclear, but some studies have implicated variations in DNA methylation. In a mouse model, Siklenka et al. found that alterations in histone methylation during sperm formation in one generation leads to reduced survival and developmental abnormalities in three subsequent generations (see the Perspective by McCarrey). Although changes in DNA methylation were not observed, altered sperm RNA content and abnormal gene expression in offspring were measured. Thus, chromatin may act as a mediator of molecular memory in transgenerational inheritance. Science , this issue p. 10.1126/science.aab2006 ; see also p. 634

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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