Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding-Reference-Cited by-同舟云学术

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding

Published:2019-06-28 Issue:6447 Volume:364 Page:1271-1274
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rossi Mark A.¹^ORCID,Basiri Marcus L.¹^ORCID,McHenry Jenna A.¹^ORCID,Kosyk Oksana¹,Otis James M.¹,van den Munkhof Hanna E.¹^ORCID,Bryois Julien²^ORCID,Hübel Christopher²³⁴^ORCID,Breen Gerome³⁴^ORCID,Guo Wilson¹,Bulik Cynthia M.¹²⁵^ORCID,Sullivan Patrick F.²⁶^ORCID,Stuber Garret D.¹⁷⁸^ORCID

Affiliation:

1. Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.

2. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

3. Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK.

4. UK National Institute for Health Research Biomedical Research Centre at South London and Maudsley Hospital, London, UK.

5. Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.

6. Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

7. Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

8. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Brain changes after overeating A brain region called the lateral hypothalamic area is an integral node in the neurocircuitry controlling feeding behavior. In a mouse model of obesity, Rossi et al. found that a distinct class of neurons within this region acts as a brake on feeding, suppressing food intake (see the Perspective by Borgland). These neurons were potently and uniquely modified by diet-induced obesity. Thus, discrete populations of lateral hypothalamic area neurons are fundamental regulators of feeding behavior that might be targeted to treat eating disorders. Science , this issue p. 1271 ; see also p. 1233

Funder

National Institute of Mental Health

National Institute on Drug Abuse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

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