Mitotic Golgi Partitioning Is Driven by the Membrane-Fissioning Protein CtBP3/BARS

Author:

Carcedo Cristina Hidalgo12,Bonazzi Matteo12,Spanò Stefania12,Turacchio Gabriele12,Colanzi Antonino12,Luini Alberto12,Corda Daniela12

Affiliation:

1. Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy.

2. Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy.

Abstract

Organelle inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G 2 -to-prophase transition of the cell cycle, and hence cell division.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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