Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set-Reference-Cited by-同舟云学术

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set

Published:2020-12-18 Issue:6523 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kebschull Justus M.¹^ORCID,Richman Ethan B.¹²³^ORCID,Ringach Noam¹^ORCID,Friedmann Drew¹^ORCID,Albarran Eddy²,Kolluru Sai Saroja³⁴⁵,Jones Robert C.³⁴^ORCID,Allen William E.¹²³⁶^ORCID,Wang Ying⁷,Cho Seung Woo⁸^ORCID,Zhou Huaijun⁷^ORCID,Ding Jun B.⁹¹⁰^ORCID,Chang Howard Y.⁸¹¹^ORCID,Deisseroth Karl³¹¹¹²^ORCID,Quake Stephen R.³⁴⁵^ORCID,Luo Liqun¹¹¹^ORCID

Affiliation:

1. Department of Biology, Stanford University, Stanford, CA 94305, USA.

2. Neurosciences Program, Stanford University, Stanford, CA 94305, USA.

3. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

4. Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.

5. Chan Zuckerberg Biohub, Stanford, CA 94305, USA.

6. Society of Fellows, Harvard University, Cambridge, MA 02138, USA.

7. Department of Animal Science, University of California, Davis, CA 95616, USA.

8. Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.

9. Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

10. Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.

11. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

12. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

Abstract

Cerebellar evolution Cerebellar nuclei, substructures of the cerebellum, transfer information from the cerebellum to other parts of the brain. Using single-cell transcriptomics, Kebschull et al. have now identified a conserved pattern of cerebellar nuclei structure that has been repeated through evolution (see the Perspective by Hatten). Ranging from mice to chickens to humans, cerebellar nuclei are made up of region-specific excitatory neurons and region-invariant inhibitory neurons. In humans, a facet connecting the cerebellum to the frontal cortex is enhanced. Science , this issue p. eabd5059 ; see also p. 1411

Funder

Howard Hughes Medical Institute

Jane Coffin Childs Memorial Fund for Medical Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference72 articles.

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