Delivery of Epitopes by the Salmonella Type III Secretion System for Vaccine Development-Reference-Cited by-同舟云学术

Delivery of Epitopes by the Salmonella Type III Secretion System for Vaccine Development

Published:1998-07-24 Issue:5376 Volume:281 Page:565-568
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rüssmann Holger¹,Shams Homayoun¹,Poblete Fernando¹,Fu Yixin¹,Galán Jorge E.¹,Donis Ruben O.¹

Affiliation:

1. H. Rüssmann, Y. Fu, J. E. Galán, Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794–5222, USA. H. Shams, F. Poblete, R. O. Donis, Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583–0905, USA.

Abstract

Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I–restricted immune responses. Viral epitopes were successfully delivered to the host-cell cytosol by using the type III protein secretion system of S. typhimurium . This resulted in class I–restricted immune responses that protected vaccinated animals against lethal infection. This approach may allow the efficient use of S. typhimurium as an antigen delivery system to control infections by pathogens that require this type of immune response for protection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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