Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates-Reference-Cited by-同舟云学术

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Published:2021-09-17 Issue:6561 Volume:373 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Corbett Kizzmekia S.¹^ORCID,Nason Martha C.²^ORCID,Flach Britta¹,Gagne Matthew¹^ORCID,O’Connell Sarah¹,Johnston Timothy S.¹^ORCID,Shah Shruti N.¹^ORCID,Edara Venkata Viswanadh³^ORCID,Floyd Katharine³^ORCID,Lai Lilin³,McDanal Charlene⁴,Francica Joseph R.¹^ORCID,Flynn Barbara¹,Wu Kai⁵,Choi Angela⁵^ORCID,Koch Matthew⁵,Abiona Olubukola M.¹^ORCID,Werner Anne P.¹,Moliva Juan I.¹,Andrew Shayne F.¹^ORCID,Donaldson Mitzi M.¹,Fintzi Jonathan¹^ORCID,Flebbe Dillon R.¹,Lamb Evan¹^ORCID,Noe Amy T.¹^ORCID,Nurmukhambetova Saule T.¹,Provost Samantha J.¹,Cook Anthony⁶,Dodson Alan⁶^ORCID,Faudree Andrew⁶^ORCID,Greenhouse Jack⁶^ORCID,Kar Swagata⁶^ORCID,Pessaint Laurent⁶^ORCID,Porto Maciel⁶,Steingrebe Katelyn⁶^ORCID,Valentin Daniel⁶,Zouantcha Serge⁶,Bock Kevin W.⁷^ORCID,Minai Mahnaz⁷,Nagata Bianca M.⁷^ORCID,van de Wetering Renee¹^ORCID,Boyoglu-Barnum Seyhan¹,Leung Kwanyee¹^ORCID,Shi Wei¹,Yang Eun Sung¹^ORCID,Zhang Yi¹^ORCID,Todd John-Paul M.¹^ORCID,Wang Lingshu¹^ORCID,Alvarado Gabriela S.¹,Andersen Hanne⁶^ORCID,Foulds Kathryn E.¹^ORCID,Edwards Darin K.⁵,Mascola John R.¹^ORCID,Moore Ian N.⁷^ORCID,Lewis Mark G.⁶^ORCID,Carfi Andrea⁵,Montefiori David⁴^ORCID,Suthar Mehul S.³⁸^ORCID,McDermott Adrian¹^ORCID,Roederer Mario¹^ORCID,Sullivan Nancy J.¹^ORCID,Douek Daniel C.¹,Graham Barney S.¹^ORCID,Seder Robert A.¹^ORCID

Affiliation:

1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Department of Pediatrics, Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA.

4. Department of Surgery, Duke University Medical Center, Durham, NC 27708, USA.

5. Moderna Inc., Cambridge, MA 02139, USA.

6. Bioqual Inc., Rockville, MD 20850, USA.

7. Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

8. Department of Microbiology and Immunology, Atlanta, GA 30329, USA.

Abstract

Antibodies dovetail with protection Immune correlates of protection are clinical end points used to gauge vaccine-induced immunogenicity and protection. Corbett et al . studied nonhuman primate (NHP) immune responses to various doses of the mRNA-1273 (Moderna) vaccine to provide a range of immune responses and protective outcomes. They determined that circulating spike protein–specific antibodies correlated with protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the airways. Passively transferred NHP antibodies were sufficient to mediate protection against SARS-CoV-2 challenge in hamsters, emphasizing that antibodies are mechanistic correlates. Protection of the lower respiratory tract required lower serum antibody concentrations, possibly explaining why most current vaccines are highly effective against severe lower airway disease. The higher antibody threshold required for reducing upper airway infection has potential implications for boosting to limit transmission. —STS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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