The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

Author:

Abi-Rached Laurent1,Jobin Matthew J.23,Kulkarni Subhash1,McWhinnie Alasdair4,Dalva Klara5,Gragert Loren6,Babrzadeh Farbod7,Gharizadeh Baback7,Luo Ma89,Plummer Francis A.89,Kimani Joshua10,Carrington Mary1112,Middleton Derek13,Rajalingam Raja14,Beksac Meral5,Marsh Steven G. E.415,Maiers Martin6,Guethlein Lisbeth A.1,Tavoularis Sofia16,Little Ann-Margaret415,Green Richard E.17,Norman Paul J.1,Parham Peter1

Affiliation:

1. Department of Structural Biology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Anthropology, Santa Clara University, Santa Clara, 95050, USA.

3. Department of Anthropology, Stanford University, Stanford, CA 94305, USA.

4. Anthony Nolan Research Institute, Royal Free Hospital, London NW3 2QG, UK.

5. Department of Hematology, Ankara University, 06520 Ankara, Turkey.

6. National Marrow Donor Program, Minneapolis, MN 55413, USA.

7. Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, CA 94304, USA.

8. Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Manitoba R3E 3R2, Canada.

9. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

10. Department of Medical Microbiology, University of Nairobi, Nairobi 00202, Kenya.

11. Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702, USA.

12. Ragon Institute of MGH, MIT and Harvard, Boston, MA 02129, USA.

13. Division of Immunology, School of Infection and Host Defense, University of Liverpool, Transplant Immunology, Royal Liverpool University Hospital, Liverpool L7 8XP, UK.

14. UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA.

15. UCL Cancer Institute, University College London, Royal Free Campus, London WC1E 6BT, UK.

16. Canadian Blood Services, Head Office, HLA Laboratory, Ottawa, Ontario KIG 4J5, Canada.

17. Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

Abstract

Viral defense and embryo implantation mechanisms have been shaped by contributions from Neandertal and Denisovan genes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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