Taurine deficiency as a driver of aging-Reference-Cited by-同舟云学术

Taurine deficiency as a driver of aging

Published:2023-06-09 Issue:6649 Volume:380 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Singh Parminder¹^ORCID,Gollapalli Kishore²^ORCID,Mangiola Stefano³⁴⁵⁶^ORCID,Schranner Daniela⁷⁸^ORCID,Yusuf Mohd Aslam⁹^ORCID,Chamoli Manish¹⁰^ORCID,Shi Sting L.²^ORCID,Lopes Bastos Bruno¹¹^ORCID,Nair Tripti¹²^ORCID,Riermeier Annett⁷,Vayndorf Elena M.¹³^ORCID,Wu Judy Z.¹³,Nilakhe Aishwarya¹^ORCID,Nguyen Christina Q.¹³,Muir Michael¹³^ORCID,Kiflezghi Michael G.¹³^ORCID,Foulger Anna¹⁰^ORCID,Junker Alex¹⁴^ORCID,Devine Jack¹⁴,Sharan Kunal¹⁵^ORCID,Chinta Shankar J.¹⁰^ORCID,Rajput Swati¹⁶^ORCID,Rane Anand¹⁰^ORCID,Baumert Philipp⁷^ORCID,Schönfelder Martin⁷^ORCID,Iavarone Francescopaolo¹⁷^ORCID,di Lorenzo Giorgia¹⁷^ORCID,Kumari Swati¹^ORCID,Gupta Alka¹^ORCID,Sarkar Rajesh¹^ORCID,Khyriem Costerwell¹⁸¹⁹^ORCID,Chawla Amanpreet S.²⁰²¹,Sharma Ankur¹⁸¹⁹^ORCID,Sarper Nazan²²^ORCID,Chattopadhyay Naibedya¹⁶^ORCID,Biswal Bichitra K.¹^ORCID,Settembre Carmine¹⁷²³^ORCID,Nagarajan Perumal²⁴²⁵^ORCID,Targoff Kimara L.²⁶^ORCID,Picard Martin¹⁴^ORCID,Gupta Sarika¹^ORCID,Velagapudi Vidya²⁷,Papenfuss Anthony T.³⁴^ORCID,Kaya Alaattin²⁸^ORCID,Ferreira Miguel Godinho¹¹^ORCID,Kennedy Brian K.²⁹³⁰³¹^ORCID,Andersen Julie K.¹⁰,Lithgow Gordon J.¹⁰^ORCID,Ali Abdullah Mahmood³²^ORCID,Mukhopadhyay Arnab¹²^ORCID,Palotie Aarno²⁷³³³⁴,Kastenmüller Gabi⁸^ORCID,Kaeberlein Matt¹³^ORCID,Wackerhage Henning⁷,Pal Bhupinder³⁴⁵⁶^ORCID,Yadav Vijay K.¹²¹⁵³⁵^ORCID

Affiliation:

1. Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.

2. Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

3. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

4. Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.

5. School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia.

6. Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.

7. Exercise Biology Group, Technical University of Munich, Munich, Germany.

8. Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.

9. Department of Bioengineering, Integral University, Lucknow, India.

10. Buck Institute for Research on Aging, Novato, CA, USA.

11. Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France.

12. Molecular Aging Laboratory, National Institute of Immunology, New Delhi, India.

13. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.

14. Department of Neurology, Columbia University, New York, NY, USA.

15. Mouse Genetics Project, Wellcome Sanger Institute, Cambridge, UK.

16. Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.

17. Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.

18. Harry Perkins Institute of Medical Research, Perth, WA, Australia.

19. Curtin Medical School, Curtin University, Perth, WA, Australia.

20. Immunobiology Laboratory, National Institute of Immunology, New Delhi, India.

21. MRC-Protein Phosphorylation and Ubiquitination Unit, University of Dundee, Dundee, UK.

22. Pediatrics and Pediatric Hematology, Kocaeli University Hospital, Kocaeli, Turkey.

23. Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.

24. Primate Research Facility, National Institute of Immunology, New Delhi, India.

25. Small Animal Research Facility, National Institute of Immunology, New Delhi, India.

26. Division of Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA.

27. Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.

28. Department of Biology, Virginia Commonwealth University, Richmond, VA, USA.

29. Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

30. Centre for Healthy Longevity, National University Health System, Singapore, Singapore.

31. Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

32. Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

33. Broad Institute of Harvard and MIT, Cambridge, MA, USA.

34. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.

35. Department of Genetics and Development, Columbia University, New York, NY, USA.

Abstract

Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.abn9257

Reference131 articles.

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