Affiliation:
1. Section of Neurobiology, Physiology and Behavior, University of California at Davis, Davis, CA 95616, USA.
Abstract
Large (more than 16-fold) differences in susceptibility to disruption of juvenile male reproductive development by 17β-estradiol (E
2
) were detected between strains of mice. Effects of strain, E
2
dose, and the interaction of strain and E
2
dose on testes weight and spermatogenesis were all highly significant (
P
< 0.0001). Spermatid maturation was eliminated by low doses of E
2
in strains such as C57BL/6J and C17/Jls. In contrast, mice of the widely used CD-1 line, which has been selected for large litter size, showed little or no inhibition of spermatid maturation even in response to 16 times as much E
2
. Product safety bioassays conducted with animals selected for fecundity may greatly underestimate disruption of male reproductive development by estradiol and environmental estrogenic compounds.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
239 articles.
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