Affiliation:
1. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.
2. Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.
Abstract
Order in the cytoplasm
Extracts of the very large eggs of the African clawed frog,
Xenopus laevis
, have proven a valuable model system for the study of cell division. Cheng and Ferrell found that after homogenization, such cytoplasm can reorganize back into cell-like structures and undergo multiple rounds of division (see the Perspective by Mitchison and Field). This reorganization apparently occurs without the usual factors that are known to lead to such structural changes during cell division, such as F-actin, myosin II, various individual kinesins, aurora kinase A, or DNA. What is required is energy from adenosine triphosphate, microtubule polymerization, cytoplasmic dynein activity, and a specific kinase-involved cell cycle progression. Nongenetic information in the cytoplasm is apparently sufficient for basic spatial organization of the cell.
Science
, this issue p.
631
; see also p.
569
Funder
National Institutes of Health
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
55 articles.
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