Effectiveness of Anthracycline Against Experimental Prion Disease in Syrian Hamsters-Reference-Cited by-同舟云学术

Effectiveness of Anthracycline Against Experimental Prion Disease in Syrian Hamsters

Published:1997-05-16 Issue:5315 Volume:276 Page:1119-1121
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tagliavini F.¹²³⁴⁵,McArthur R. A.¹²³⁴⁵,Canciani B.¹²³⁴⁵,Giaccone G.¹²³⁴⁵,Porro M.¹²³⁴⁵,Bugiani M.¹²³⁴⁵,Lievens P. M.-J.¹²³⁴⁵,Bugiani O.¹²³⁴⁵,Peri E.¹²³⁴⁵,Dall’Ara P.¹²³⁴⁵,Rocchi M.¹²³⁴⁵,Poli G.¹²³⁴⁵,Forloni G.¹²³⁴⁵,Bandiera T.¹²³⁴⁵,Varasi M.¹²³⁴⁵,Suarato A.¹²³⁴⁵,Cassutti P.¹²³⁴⁵,Cervini M. A.¹²³⁴⁵,Lansen J.¹²³⁴⁵,Salmona M.¹²³⁴⁵,Post C.¹²³⁴⁵

Affiliation:

1. F. Tagliavini, B. Canciani, G. Giaccone, M. Porro, M. Bugiani, P. M.-J. Lievens, O. Bugiani, Istituto Nazionale Neurologico Carlo Besta, via Celoria 11, 20133 Milano, Italy.

2. R. A. McArthur, T. Bandiera, M. Varasi, P. Cassutti, M. A. Cervini, J. Lansen, C. Post, CNS Research, Pharmacia & Upjohn SpA, viale Pasteur 10, 20014 Nerviano (MI), Italy.

3. E. Peri, P. Dall’Ara, M. Rocchi, G. Poli, Istituto di Microbiologia e Immunologia Veterinaria, Università degli Studi, via Celoria 10, 20133 Milano, Italy.

4. G. Forloni and M. Salmona, Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea, 62, 20157 Milano, Italy.

5. A. Suarato, Oncology Research, Pharmacia & Upjohn SpA, viale Pasteur 10, 20014 Nerviano (MI), Italy.

Abstract

Prion diseases are transmissible neurodegenerative conditions characterized by the accumulation of protease-resistant forms of the prion protein (PrP), termed PrPres, in the brain. Insoluble PrPres tends to aggregate into amyloid fibrils. The anthracycline 4′-iodo-4′-deoxy-doxorubicin (IDX) binds to amyloid fibrils and induces amyloid resorption in patients with systemic amyloidosis. To test IDX in an experimental model of prion disease, Syrian hamsters were inoculated intracerebrally either with scrapie-infected brain homogenate or with infected homogenate coincubated with IDX. In IDX-treated hamsters, clinical signs of disease were delayed and survival time was prolonged. Neuropathological examination showed a parallel delay in the appearance of brain changes and in the accumulation of PrPres and PrP amyloid.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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