Specific HIV integration sites are linked to clonal expansion and persistence of infected cells-Reference-Cited by-同舟云学术

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Published:2014-07-11 Issue:6193 Volume:345 Page:179-183
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Maldarelli F.¹,Wu X.²,Su L.²,Simonetti F. R.¹³,Shao W.²,Hill S.¹,Spindler J.¹,Ferris A. L.¹,Mellors J. W.⁴,Kearney M. F.¹,Coffin J. M.⁵,Hughes S. H.¹

Affiliation:

1. HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.

2. Leidos Biomedical Research, Frederick, MD 21702, USA.

3. Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, 20122 Milan, Italy.

4. Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

5. Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA.

Abstract

For HIV: Location, location, location HIV-infected cells linger even in the face of therapy, and this persistence, termed the latent reservoir, is a major hurdle for curing HIV. HIV integrates itself into the DNA of its host cells. Could that affect the latent reservoir? To find out, Maldarelli et al. drew blood from five HIV patients on antiretroviral therapy and analyzed sites where HIV had inserted itself into the blood cells' DNA (see the Perspective by Margolis and Bushman). In many cases, these sites were not random; HIV often weaseled its way into genes that help cells grow and proliferate. Where HIV integrates into the host genome may thus determine the size of the latent reservoir. Science , this issue p. 179 ; see also p. 143

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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